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| 08/11/2022 | 19:45 | Leicester City | - | Newport County | 3:0 (1:0) | |
| 19:45 | AFC Bournemouth | - | Everton FC | 4:1 (1:0) | ||
| 19:45 | Burnley FC | - | Crawley Town | 3:1 (1:1) | ||
| 19:45 | Bristol City | - | Lincoln City | 1:3 (0:2) | ||
| 19:45 | Stevenage FC | - | Charlton Athletic | 4:5 (1:0, 1:1) pso | ||
| 19:45 | Milton Keynes Dons | - | Morecambe FC | 2:0 (1:0) | ||
| 20:00 | Brentford FC | - | Gillingham FC | 5:6 (1:0, 1:1) pso | ||
| 09/11/2022 | 19:45 | West Ham United | - | Blackburn Rovers | 9:10 (1:1, 2:2) pso | |
| 19:45 | Wolverhampton Wanderers | - | Leeds United | 1:0 (0:0) | ||
| 19:45 | Nottingham Forest | - | Tottenham Hotspur | 2:0 (0:0) | ||
| 19:45 | Newcastle United | - | Crystal Palace | 3:2 (0:0, 0:0) pso | ||
| 19:45 | Southampton FC | - | Sheffield Wednesday | 6:5 (1:1, 1:1) pso | ||
| 19:45 | Arsenal FC | - | Brighton & Hove Albion | 1:3 (1:1) | ||
| 20:00 | Liverpool FC | - | Derby County | 3:2 (0:0, 0:0) pso | ||
| 20:00 | Manchester City | - | Chelsea FC | 2:0 (0:0) | ||
| 10/11/2022 | 20:00 | Manchester United | - | Aston Villa | 4:2 (0:0) |
