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| 1st(1st leg) | AC Perugia Calcio | - | Parma Calcio 1913 | 3:3 (3:2) | ||
| 2nd (2nd leg) | Parma Calcio 1913 | - | AC Perugia Calcio | 7:0 (3:0) | ||
| 1st(1st leg): 30/04/2022 14:00 | 2nd (2nd leg): 07/05/2022 14:00 | Winner: Parma Calcio 1913 | ||||
| 1st(1st leg) | Lazio Roma | - | Brescia Calcio | 1:3 (1:1) | ||
| 2nd (2nd leg) | Brescia Calcio | - | Lazio Roma | 1:2 (1:2) | ||
| 1st(1st leg): 30/04/2022 14:00 | 2nd (2nd leg): 07/05/2022 14:00 | Winner: Brescia Calcio | ||||
| 1st(1st leg) | US Cremonese | - | Frosinone Calcio | 1:2 (0:1) | ||
| 2nd (2nd leg) | Frosinone Calcio | - | US Cremonese | 0:1 (0:0) | ||
| 1st(1st leg): 30/04/2022 14:00 | 2nd (2nd leg): 07/05/2022 14:00 | Winner: Frosinone Calcio | ||||
| 1st(1st leg) | AC Monza | - | AC Pisa | 2:0 (1:0) | ||
| 2nd (2nd leg) | AC Pisa | - | AC Monza | 0:1 (0:0) | ||
| 1st(1st leg): 30/04/2022 14:00 | 2nd (2nd leg): 07/05/2022 14:00 | Winner: AC Monza | ||||
