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| 12/01/2022 | 16:30 | Atalanta | - | Venezia FC | 2:0 (1:0) | |
| 13/01/2022 | 17:00 | SSC Napoli | - | ACF Fiorentina | 2:5 (1:1, 2:2) aet | |
| 20:00 | AC Milan | - | Genoa CFC | 3:1 (0:1, 1:1) aet | ||
| 18/01/2022 | 16:30 | Lazio Roma | - | Udinese Calcio | 1:0 (0:0, 0:0) aet | |
| 20:00 | Juventus | - | Sampdoria | 4:1 (1:0) | ||
| 19/01/2022 | 16:30 | Sassuolo Calcio | - | Cagliari Calcio | 1:0 (1:0) | |
| 20:00 | Inter | - | Empoli FC | 3:2 (1:0, 2:2) aet | ||
| 20/01/2022 | 20:00 | AS Roma | - | US Lecce | 3:1 (1:1) |
