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| 04/12/2022 | 13:30 | ACD Nardò | - | Afragolese | 2:1 | |
| 13:30 | US Bitonto | - | Martina | 2:2 | ||
| 13:30 | Cavese | - | Casarano | 2:1 | ||
| 13:30 | FC Francavilla | - | FBC Gravina | 1:1 | ||
| 13:30 | Gladiator | - | ASG Nocerina | 2:0 | ||
| 13:30 | Matera Calcio | - | Lavello | 3:2 | ||
| 13:30 | Sporting Fulgor Molfetta | - | Brindisi | 2:3 | ||
| 13:30 | Puteolana Internapoli | - | SS Barletta Calcio | 0:1 | ||
| 14:30 | Città di Fasano | - | Team Altamura | 0:0 |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cavese | 14 | 9 | 3 | 2 | 26:13 | 13 | 30 |
| 2 |
|
SS Barletta Calcio | 14 | 8 | 4 | 2 | 14:9 | 5 | 28 |
| 3 |
|
ACD Nardò | 14 | 6 | 8 | 0 | 15:6 | 9 | 26 |
| 4 |
|
Brindisi | 14 | 7 | 4 | 3 | 24:15 | 9 | 25 |
| 5 |
|
Città di Fasano | 14 | 6 | 5 | 3 | 22:14 | 8 | 23 |
| 6 |
|
Team Altamura | 14 | 5 | 7 | 2 | 19:13 | 6 | 22 |
| 7 |
|
Casarano | 14 | 5 | 7 | 2 | 21:16 | 5 | 22 |
| 8 |
|
Gladiator | 14 | 5 | 5 | 4 | 22:20 | 2 | 20 |
| 9 |
|
Martina | 14 | 4 | 6 | 4 | 20:22 | -2 | 18 |
| 10 |
|
Matera Calcio | 14 | 4 | 5 | 5 | 21:25 | -4 | 17 |
| 11 |
|
US Bitonto | 14 | 4 | 4 | 6 | 16:19 | -3 | 16 |
| 12 |
|
Afragolese | 14 | 3 | 6 | 5 | 21:21 | 0 | 15 |
| 13 |
|
ASG Nocerina | 14 | 3 | 6 | 5 | 18:21 | -3 | 15 |
| 14 |
|
Sporting Fulgor Molfetta | 14 | 3 | 5 | 6 | 22:24 | -2 | 14 |
| 15 |
|
Lavello | 14 | 3 | 3 | 8 | 13:27 | -14 | 12 |
| 16 |
|
FC Francavilla | 14 | 2 | 4 | 8 | 14:21 | -7 | 10 |
| 17 |
|
FBC Gravina | 14 | 0 | 9 | 5 | 7:16 | -9 | 9 |
| 18 |
|
Puteolana Internapoli | 14 | 0 | 7 | 7 | 10:23 | -13 | 7 |
| Promotion | |
| Playoffs | |
| Playoffs | |
| Relegation |
