Friendlies Clubs   M. W D L goals
  at home 1 0 1 0 2 : 2
  1 0 1 0 2 : 2
Premier League   M. W D L goals
  at home 2 2 0 0 6 : 0
  Away 2 1 0 1 3 : 4
  4 3 0 1 9 : 4
Championship   M. W D L goals
  at home 8 4 2 2 15 : 7
  Away 8 2 1 5 8 : 11
  16 6 3 7 23 : 18
FA Cup   M. W D L goals
  at home 1 0 0 1 1 : 3
  Away 1 0 1 0 2 : 2
  2 0 1 1 3 : 5
League Cup   M. W D L goals
  at home 1 0 0 1 0 : 2
  Away 2 1 0 1 3 : 3
  3 1 0 2 3 : 5
League One   M. W D L goals
  at home 2 0 1 1 1 : 4
  Away 2 1 1 0 3 : 1
  4 1 2 1 4 : 5
overall   M. W D L goals
  at home 15 6 4 5 25 : 18
  Away 15 5 3 7 19 : 21
  Neutral Place 0 0 0 0 0 : 0
  30 11 7 12 44 : 39
Friendlies Clubs
2017 Week Brentford FC - Southampton FC 2:2 (1:0)
Premier League
2022/2023 7. Round Southampton FC - Brentford FC 0:2 (0:1)
2022/2023 22. Round Brentford FC - Southampton FC 3:0 (2:0)
2021/2022 36. Round Brentford FC - Southampton FC 3:0 (2:0)
2021/2022 18. Round Southampton FC - Brentford FC 4:1 (2:1)
Championship
1952/1953 7. Round Southampton FC - Brentford FC 0:2
1952/1953 3. Round Brentford FC - Southampton FC 3:0
1951/1952 5. Round Southampton FC - Brentford FC 2:1
1951/1952 5. Round Brentford FC - Southampton FC 1:2
1950/1951 10. Round Southampton FC - Brentford FC 2:1
1950/1951 5. Round Brentford FC - Southampton FC 4:0
1949/1950 8. Round Southampton FC - Brentford FC 2:3
1949/1950 3. Round Brentford FC - Southampton FC 0:1
1948/1949 8. Round Southampton FC - Brentford FC 2:0
1948/1949 3. Round Brentford FC - Southampton FC 0:0
1947/1948 9. Round Southampton FC - Brentford FC 2:1
1947/1948 5. Round Brentford FC - Southampton FC 2:2
1934/1935 8. Round Brentford FC - Southampton FC 3:2
1934/1935 3. Round Southampton FC - Brentford FC 1:0
1933/1934 8. Round Southampton FC - Brentford FC 0:0
1933/1934 3. Round Brentford FC - Southampton FC 2:0
FA Cup
2004/2005 Round of 16 Brentford FC - Southampton FC 1:3 (1:1)
2004/2005 Round of 16 Southampton FC - Brentford FC 2:2 (2:1)
League Cup
2020/2021 2. Round Southampton FC - Brentford FC 0:2 (0:2)
1997/1998 2. Round Brentford FC - Southampton FC 0:2 (0:2)
1997/1998 2. Round Southampton FC - Brentford FC 3:1 (1:0)
League One
2010/2011 45. Round Brentford FC - Southampton FC 0:3 (0:2)
2010/2011 20. Round Southampton FC - Brentford FC 0:2 (0:2)
2009/2010 25. Round Brentford FC - Southampton FC 1:1 (0:1)
2009/2010 4. Round Southampton FC - Brentford FC 1:1 (0:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking