Serie A   M. W D L goals
  at home 3 2 0 1 5 : 5
  Away 3 1 2 0 4 : 3
  6 3 2 1 9 : 8
Serie B   M. W D L goals
  at home 1 0 1 0 1 : 1
  Away 1 0 1 0 0 : 0
  2 0 2 0 1 : 1
overall   M. W D L goals
  at home 4 2 1 1 6 : 6
  Away 4 1 3 0 4 : 3
  Neutral Place 0 0 0 0 0 : 0
  8 3 4 1 10 : 9
Serie A
2023/2024 33. Round Sassuolo Calcio - US Lecce 0:3 (0:2)
2023/2024 8. Round US Lecce - Sassuolo Calcio 1:1 (0:1)
2022/2023 24. Round US Lecce - Sassuolo Calcio 0:1 (0:0)
2022/2023 2. Round Sassuolo Calcio - US Lecce 1:0 (1:0)
2019/2020 30. Round Sassuolo Calcio - US Lecce 4:2 (1:1)
2019/2020 11. Round US Lecce - Sassuolo Calcio 2:2 (2:1)
Serie B
2009/2010 42. Round US Lecce - Sassuolo Calcio 0:0 (0:0)
2009/2010 21. Round Sassuolo Calcio - US Lecce 1:1 (0:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking