| 1. Round | 15/09/2005 | AS Roma | - | Aris Saloniki | 5:1 |  |
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| 1. Round | 29/09/2005 | Aris Saloniki | - | AS Roma | 0:0 | ||||
| Group E | 24/11/2005 | AS Roma | - | RC Strasbourg | 1:1 | ||||
| Group E | 01/12/2005 | Crvena Zvezda | - | AS Roma | 3:1 | |
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| Group E | 14/12/2005 | AS Roma | - | FC Basel 1893 | 3:1 | ||||
| 3. Round | 23/02/2006 | AS Roma | - | Club Brugge KV | 2:1 | ||||
| Round of 16 | 09/03/2006 | Middlesbrough FC | - | AS Roma | 1:0 | ||||
| Round of 16 | 15/03/2006 | AS Roma | - | Middlesbrough FC | 2:1 | |
Italy
