| 5. Round | 01/02/2022 | Club Tijuana [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 6. Round | 05/02/2022 | Mazatlán FC [Women] | - | UANL Tigres [Women] | 2:4 |  |
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| 7. Round | 11/02/2022 | UANL Tigres [Women] | - | Puebla FC [Women] | 2:0 | ||||
| 3. Round | 24/02/2022 | FC Juárez [Women] | - | UANL Tigres [Women] | 1:2 | ||||
| 8. Round | 01/03/2022 | CF Pachuca [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 10. Round | 14/03/2022 | Deportivo Toluca [Women] | - | UANL Tigres [Women] | 2:2 | |
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| 11. Round | 18/03/2022 | UANL Tigres [Women] | - | Cruz Azul [Women] | 4:0 |  |
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| 12. Round | 22/03/2022 | UANL Tigres [Women] | - | Club León [Women] | 6:0 | |
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| 13. Round | 28/03/2022 | Atlético San Luis [Women] | - | UANL Tigres [Women] | 0:6 | |
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| 14. Round | 02/04/2022 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 9. Round | 15/04/2022 | UANL Tigres [Women] | - | Gallos Blancos [Women] | 0:0 | ||||
| 15. Round | 19/04/2022 | UANL Tigres [Women] | - | Santos Laguna [Women] | 4:1 | ||||
| 16. Round | 26/04/2022 | CF Monterrey [Women] | - | UANL Tigres [Women] | 0:0 | |
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| 17. Round | 02/05/2022 | UANL Tigres [Women] | - | CF América [Women] | 1:1 | |
USA
Mexico