Borussia Dortmund's Germany midfielder Sven Bender has been ruled out of Wednesday's Champions League game at Marseille, while Nuri Sahin is rated as doubtful.

Bender sprained his right ankle after an hour of Saturday's 1-0 league defeat at home to Bayer Leverkusen, while Sahin had to be helped off eight minutes from time and a scan revealed a ligament tear in his right ankle.

The Turkey midfielder has not been ruled out of the clash at Marseille's Stade Velodrome.

"We lost 1-0, but that's actually the least of our problems," said coach Jurgen Klopp.

With midfielder Ilkay Gundogan, defender Mats Hummels, Neven Subotic and Marcel Schmelzer already on the list of absentees, Klopp's injury worries show no sign of easing.

Klopp is down to his fourth choice at centre-back, having played Bender out of position in the 3-1 win over Napoli in their last Champions League match, as Manuel Friedrich is cup-tied and Hummels injured.

Last season's finalists Dortmund can assure themselves of a place in the knock-out stages with a defeat of pointless Marseille but could also progres with just a draw if Group F leaders Arsenal beat Napoli away.

Dortmund's defeat to Leverkusen leaves them third in the Bundesliga, seven points behind Leverkusen and 10 adrift of leaders Bayern Munich.