| 2. Round | 21/08/2021 | FC Speyer 09 | - | Wormatia Worms | 0:4 | ||||
| 4. Round | 28/08/2021 | Wormatia Worms | - | SV 07 Elversberg II | 3:1 | ||||
| 5. Round | 05/09/2021 | SV Röchling Völklingen | - | Wormatia Worms | 0:3 | ||||
| 6. Round | 11/09/2021 | Wormatia Worms | - | FV Eppelborn | 2:0 |  |
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| 7. Round | 18/09/2021 | TuS Mechtersheim | - | Wormatia Worms | 1:1 | |
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| 8. Round | 22/09/2021 | Wormatia Worms | - | TSG Pfeddersheim | 7:0 | ||||
| 9. Round | 25/09/2021 | FV Dudenhofen | - | Wormatia Worms | 0:2 | ||||
| 10. Round | 02/10/2021 | Wormatia Worms | - | FSV Jägersburg | 6:0 | ||||
| 12. Round | 16/10/2021 | FC Hertha Wiesbach | - | Wormatia Worms | 1:2 | ||||
| 13. Round | 23/10/2021 | Wormatia Worms | - | FC Speyer 09 | 2:0 | ||||
| 14. Round | 27/10/2021 | Wormatia Worms | - | Arminia Ludwigshafen | 3:3 | ||||
| 18. Round | 20/11/2021 | Wormatia Worms | - | TuS Mechtersheim | 2:1 |
Germany