| 22. Round | 22/01/2022 | Viktoria Köln | - | SC Verl | 5:2 |  |
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| 23. Round | 26/01/2022 | SC Verl | - | SV Meppen | 0:1 | ||||
| 24. Round | 31/01/2022 | Eintracht Braunschweig | - | SC Verl | 1:1 | ||||
| 25. Round | 05/02/2022 | SC Verl | - | Hallescher FC | 0:0 | ||||
| 28. Round | 26/02/2022 | 1. FC Kaiserslautern | - | SC Verl | 2:1 | |
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| 29. Round | 04/03/2022 | TSV 1860 München | - | SC Verl | 2:0 | |
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| 31. Round | 19/03/2022 | TSV Havelse | - | SC Verl | 1:3 | |
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| 27. Round | 29/03/2022 | SC Verl | - | FSV Zwickau | 0:0 | ||||
| 32. Round | 02/04/2022 | SC Verl | - | SC Freiburg II | 3:1 | ||||
| 33. Round | 11/04/2022 | VfL Osnabrück | - | SC Verl | 3:2 |  |
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| 34. Round | 17/04/2022 | SC Verl | - | 1. FC Magdeburg | 4:5 | |
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| 37. Round | 06/05/2022 | Borussia Dortmund II | - | SC Verl | 1:2 | ||||
| 38. Round | 14/05/2022 | SC Verl | - | MSV Duisburg | 1:1 |
Germany