| 5. Round | 18/10/2020 | PEC Zwolle | - | PSV Eindhoven | 0:3 | ||||
| 6. Round | 25/10/2020 | Vitesse | - | PSV Eindhoven | 2:1 | ||||
| 7. Round | 01/11/2020 | PSV Eindhoven | - | ADO Den Haag | 4:0 | ||||
| 8. Round | 08/11/2020 | PSV Eindhoven | - | Willem II | 3:0 | ||||
| 10. Round | 29/11/2020 | PSV Eindhoven | - | Sparta Rotterdam | 1:0 | ||||
| 11. Round | 06/12/2020 | sc Heerenveen | - | PSV Eindhoven | 2:2 | ||||
| 13. Round | 19/12/2020 | RKC Waalwijk | - | PSV Eindhoven | 1:4 | ||||
| 14. Round | 22/12/2020 | PSV Eindhoven | - | VVV-Venlo | 4:1 |  |
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| 18. Round | 23/01/2021 | PSV Eindhoven | - | RKC Waalwijk | 2:0 | ||||
| 19. Round | 26/01/2021 | FC Emmen | - | PSV Eindhoven | 0:2 | ||||
| 23. Round | 21/02/2021 | PSV Eindhoven | - | Vitesse | 3:1 | ||||
| 25. Round | 07/03/2021 | Fortuna Sittard | - | PSV Eindhoven | 1:3 | ||||
| 32. Round | 09/05/2021 | Willem II | - | PSV Eindhoven | 0:2 |
Germany