| 12. Round | 14/11/2021 | SG Wattenscheid 09 | - | FCE Rheine | 4:2 | ||||
| 14. Round | 13/02/2022 | FCE Rheine | - | TSG Sprockhövel | 2:1 | ||||
| 18. Round | 06/03/2022 | FCE Rheine | - | FC Gütersloh | 0:2 | ||||
| 19. Round | 13/03/2022 | TuS Haltern | - | FCE Rheine | 2:3 | ||||
| 17. Round | 16/03/2022 | SpVgg Vreden | - | FCE Rheine | 0:3 | ||||
| 21. Round | 27/03/2022 | Preußen Münster II | - | FCE Rheine | 3:1 | ||||
| 20. Round | 03/04/2022 | FCE Rheine | - | TuS Erndtebrück | 2:0 |
Germany