| 1. Round | 24/07/2022 | FC Schalke 04 II | - | SV 19 Straelen | 1:0 | ||||
| 2. Round | 31/07/2022 | 1. FC Köln II | - | FC Schalke 04 II | 1:3 | ||||
| 3. Round | 07/08/2022 | FC Schalke 04 II | - | SV Lippstadt 08 | 1:3 | ||||
| 4. Round | 13/08/2022 | SV Rödinghausen | - | FC Schalke 04 II | 2:0 | ||||
| 5. Round | 20/08/2022 | Fortuna Köln | - | FC Schalke 04 II | 0:0 | ||||
| 15. Round | 05/11/2022 | 1. FC Bocholt | - | FC Schalke 04 II | 2:8 | ||||
| 16. Round | 11/11/2022 | FC Schalke 04 II | - | Alemannia Aachen | 0:0 |  |
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| 17. Round | 18/11/2022 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 1:1 | ||||
| 24. Round | 26/02/2023 | FC Schalke 04 II | - | Rot-Weiß Oberhausen | 1:4 | |
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| 28. Round | 31/03/2023 | FC Schalke 04 II | - | Wuppertaler SV | 1:0 | ||||
| 26. Round | 05/04/2023 | FC Schalke 04 II | - | Fortuna Düsseldorf II | 0:2 | ||||
| 29. Round | 09/04/2023 | Rot Weiss Ahlen | - | FC Schalke 04 II | 1:3 | ||||
| 30. Round | 15/04/2023 | FC Schalke 04 II | - | SG Wattenscheid 09 | 3:0 | ||||
| 31. Round | 23/04/2023 | SC Wiedenbrück | - | FC Schalke 04 II | 4:1 | ||||
| 33. Round | 05/05/2023 | Alemannia Aachen | - | FC Schalke 04 II | 0:1 |
Togo