| 4. Round | 12/09/2021 | 1. FC Mönchengladbach | - | SC Velbert | 0:4 |  |
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| 5. Round | 18/09/2021 | SC Velbert | - | FSV Duisburg | 2:0 | ||||
| 6. Round | 26/09/2021 | VfB 03 Hilden | - | SC Velbert | 3:3 | ||||
| 8. Round | 10/10/2021 | SC Velbert | - | Sportfreunde Niederwenigern | 1:2 | ||||
| 9. Round | 17/10/2021 | TV Jahn Hiesfeld | - | SC Velbert | 2:1 | ||||
| 10. Round | 24/10/2021 | SC Velbert | - | SpVg Schonnebeck | 1:3 | ||||
| 11. Round | 31/10/2021 | Cronenberger SC | - | SC Velbert | 1:1 | ||||
| 12. Round | 07/11/2021 | SC Velbert | - | SC Union Nettetal | 1:1 | ||||
| 16. Round | 11/12/2021 | SC Velbert | - | TSV Meerbusch | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Bocholt | - | SC Velbert | 5:0 | ||||
| 20. Round | 06/03/2022 | SC Velbert | - | SpVgg Sterkrade-Nord | 3:1 | ||||
| 21. Round | 13/03/2022 | Schwarz-Weiß Essen | - | SC Velbert | 8:0 |  |
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| 18. Round | 16/03/2022 | SC Velbert | - | SSVg Velbert | 0:5 | ||||
| 23. Round | 27/03/2022 | DJK Teutonia St. Tönis | - | SC Velbert | 0:0 | ||||
| 22. Round | 30/03/2022 | SC Velbert | - | FC Kray | 2:4 |
Germany