| 2. Round | 19/09/2021 | Borussia Dortmund [Youth] | - | SC Paderborn 07 [Youth] | 3:1 | ||||
| 7. Round | 31/10/2021 | SC Paderborn 07 [Youth] | - | Rot-Weiss Essen [Youth] | 3:4 | ||||
| 8. Round | 27/11/2021 | Rot-Weiß Oberhausen [Youth] | - | SC Paderborn 07 [Youth] | 1:0 | ||||
| 12. Round | 19/02/2022 | SC Paderborn 07 [Youth] | - | Arminia Bielefeld [Youth] | 3:2 |  |
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| 13. Round | 05/03/2022 | FC Schalke 04 [Youth] | - | SC Paderborn 07 [Youth] | 1:0 |
Germany