| 4. Round | 13/08/2005 | Rot-Weiss Essen | - | Rot-Weiß Oberhausen | 2:1 | ||||
| 5. Round | 24/08/2005 | Wuppertaler SV | - | Rot-Weiss Essen | 0:0 | ||||
| 7. Round | 04/09/2005 | Hertha BSC II | - | Rot-Weiss Essen | 1:0 | ||||
| 10. Round | 21/09/2005 | Rot-Weiss Essen | - | FC Carl Zeiss Jena | 2:1 | ||||
| 11. Round | 24/09/2005 | Holstein Kiel | - | Rot-Weiss Essen | 3:1 |  |
|||
| 12. Round | 01/10/2005 | Rot-Weiss Essen | - | VfL Osnabrück | 2:1 | |
|||
| 13. Round | 16/10/2005 | SG Wattenscheid 09 | - | Rot-Weiss Essen | 2:2 | ||||
| 15. Round | 29/10/2005 | Rot-Weiss Essen | - | 1. FC Köln II | 3:1 | |
|||
| 16. Round | 05/11/2005 | FC St. Pauli | - | Rot-Weiss Essen | 3:0 |  |
|||
| 17. Round | 11/11/2005 | Rot-Weiss Essen | - | Hamburger SV II | 2:1 | |
|||
| 18. Round | 20/11/2005 | Werder Bremen II | - | Rot-Weiss Essen | 0:3 | ||||
| 32. Round | 13/04/2006 | Rot-Weiss Essen | - | SG Wattenscheid 09 | 0:1 | ||||
| 34. Round | 29/04/2006 | 1. FC Köln II | - | Rot-Weiss Essen | 1:1 | ||||
| 36. Round | 03/05/2006 | Hamburger SV II | - | Rot-Weiss Essen | 3:4 | |
 |
||
| 37. Round | 20/05/2006 | Rot-Weiss Essen | - | Werder Bremen II | 0:0 | ||||
| 38. Round | 27/05/2006 | Rot-Weiß Erfurt | - | Rot-Weiss Essen | 0:1 |
Germany