| 1. Round | 25/07/2021 | FC Eilenburg | - | BSG Chemie Leipzig | 1:1 | ||||
| 2. Round | 28/07/2021 | FSV 63 Luckenwalde | - | FC Eilenburg | 1:0 | ||||
| 3. Round | 01/08/2021 | FC Eilenburg | - | BFC Dynamo | 0:2 | ||||
| 4. Round | 07/08/2021 | Optik Rathenow | - | FC Eilenburg | 1:1 | ||||
| 5. Round | 13/08/2021 | FC Eilenburg | - | FC Carl Zeiss Jena | 1:3 | ||||
| 6. Round | 18/08/2021 | VfB Auerbach | - | FC Eilenburg | 2:1 | ||||
| 7. Round | 22/08/2021 | FC Eilenburg | - | TeBe Berlin | 0:2 | ||||
| 8. Round | 29/08/2021 | Union Fürstenwalde | - | FC Eilenburg | 1:1 | ||||
| 9. Round | 01/09/2021 | FC Eilenburg | - | Berliner AK 07 | 0:1 | ||||
| 10. Round | 10/09/2021 | VSG Altglienicke | - | FC Eilenburg | 6:0 | ||||
| 11. Round | 19/09/2021 | FC Eilenburg | - | 1. FC Lok Leipzig | 1:1 | ||||
| 12. Round | 25/09/2021 | Energie Cottbus | - | FC Eilenburg | 9:0 | ||||
| 13. Round | 03/10/2021 | Chemnitzer FC | - | FC Eilenburg | 2:0 |
Greece