| 1. Round | 13/08/2021 | FV Engers 07 | - | TuS Koblenz | 1:1 | ||||
| 2. Round | 21/08/2021 | TuS Koblenz | - | SG Mülheim-Kärlich | 2:0 | ||||
| 3. Round | 24/08/2021 | TSV Emmelshausen | - | TuS Koblenz | 0:2 | ||||
| 4. Round | 28/08/2021 | SV Alemannia Waldalgesheim | - | TuS Koblenz | 3:1 |  |
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| 6. Round | 11/09/2021 | TuS Koblenz | - | Hassia Bingen | 1:2 | ||||
| 13. Round | 22/10/2021 | SG Mülheim-Kärlich | - | TuS Koblenz | 2:3 |  |
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| 14. Round | 27/10/2021 | TuS Koblenz | - | TSV Emmelshausen | 1:1 | ||||
| 16. Round | 07/11/2021 | Eintracht Trier | - | TuS Koblenz | 3:1 | ||||
| 17. Round | 13/11/2021 | Hassia Bingen | - | TuS Koblenz | 0:2 | ||||
| 15. Round | 17/11/2021 | TuS Koblenz | - | SV Alemannia Waldalgesheim | 1:2 | ||||
| 18. Round | 20/11/2021 | TuS Koblenz | - | Sportfreunde Eisbachtal | 2:1 | ||||
| 19. Round | 24/11/2021 | SV Gonsenheim | - | TuS Koblenz | 1:0 | ||||
| 20. Round | 27/11/2021 | TuS Koblenz | - | FC Karbach | 0:2 | ||||
| 22. Round | 05/03/2022 | TuS Koblenz | - | 1. FC Kaiserslautern II | 4:2 |
Germany
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