| Group G | 16/09/2021 | Bayer Leverkusen | - | Ferencvárosi TC | 2:1 | ||||
| Group G | 30/09/2021 | Celtic FC | - | Bayer Leverkusen | 0:4 |  |
|||
| Group G | 21/10/2021 | Real Betis | - | Bayer Leverkusen | 1:1 | ||||
| Group G | 04/11/2021 | Bayer Leverkusen | - | Real Betis | 4:0 |  |
|||
| Group G | 25/11/2021 | Bayer Leverkusen | - | Celtic FC | 3:2 | ||||
| Group G | 09/12/2021 | Ferencvárosi TC | - | Bayer Leverkusen | 1:0 | ||||
| Round of 16 | 10/03/2022 | Atalanta | - | Bayer Leverkusen | 3:2 | ||||
| Round of 16 | 17/03/2022 | Bayer Leverkusen | - | Atalanta | 0:1 |
France
