| 1. Round | 23/08/1980 | Hansa Rostock | - | 1. FC Lokomotive Leipzig | 2:2 | ||||
| 2. Round | 30/08/1980 | 1. FC Lokomotive Leipzig | - | BSG Chemie Böhlen | 2:0 |  |
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| 3. Round | 06/09/1980 | BFC Dynamo | - | 1. FC Lokomotive Leipzig | 3:0 | ||||
| 4. Round | 13/09/1980 | 1. FC Lokomotive Leipzig | - | BSG Stahl Riesa | 3:0 | ||||
| 6. Round | 27/09/1980 | 1. FC Lokomotive Leipzig | - | HFC Chemie | 3:1 | ||||
| 21. Round | 15/04/1981 | 1. FC Lokomotive Leipzig | - | Dynamo Dresden | 2:1 | ||||
| 22. Round | 25/04/1981 | FC Vorwärts Frankfurt/Oder | - | 1. FC Lokomotive Leipzig | 1:2 | ||||
| 23. Round | 09/05/1981 | 1. FC Lokomotive Leipzig | - | 1. FC Magdeburg | 1:1 | ||||
| 25. Round | 23/05/1981 | 1. FC Lokomotive Leipzig | - | Rot-Weiß Erfurt | 4:1 | ||||
| 26. Round | 30/05/1981 | FC Karl-Marx-Stadt | - | 1. FC Lokomotive Leipzig | 6:1 |
Germany