| 10. Round | 04/09/2021 | TSV Karlburg | - | Vatan Spor Aschaffenburg | 1:1 | ||||
| 19. Round | 06/11/2021 | TSV Großbardorf | - | TSV Karlburg | 1:0 | ||||
| 20. Round | 13/11/2021 | TSV Karlburg | - | TSV Abtswind | 0:2 |  |
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| 21. Round | 20/11/2021 | Würzburger FV | - | TSV Karlburg | 1:1 | ||||
| 23. Round | 05/03/2022 | SpVgg Ansbach | - | TSV Karlburg | 2:0 | ||||
| 24. Round | 12/03/2022 | TSV Karlburg | - | DJK Gebenbach | 0:3 | ||||
| 26. Round | 26/03/2022 | TSV Karlburg | - | DJK Ammerthal | 1:3 |  |
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| 25. Round | 05/04/2022 | ATSV Erlangen | - | TSV Karlburg | 2:0 | ||||
| 28. Round | 09/04/2022 | TSV Karlburg | - | DJK Vilzing | 1:2 | ||||
| 30. Round | 23/04/2022 | ASV Neumarkt | - | TSV Karlburg | 3:0 | ||||
| 31. Round | 30/04/2022 | TSV Karlburg | - | Eintracht Bamberg | 0:3 | ||||
| 27. Round | 03/05/2022 | Vatan Spor Aschaffenburg | - | TSV Karlburg | 2:0 | ||||
| 32. Round | 08/05/2022 | DJK Bamberg | - | TSV Karlburg | 1:1 | |
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| 33. Round | 14/05/2022 | TSV Karlburg | - | 1. FC Sand | 2:1 | ||||
| 34. Round | 21/05/2022 | SpVgg Bayern Hof | - | TSV Karlburg | 0:2 | |
Germany