| 3. Round | 31/07/2021 | TSV Abtswind | - | TSV Karlburg | 0:0 |  |
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| 5. Round | 07/08/2021 | ASV Cham | - | TSV Karlburg | 0:1 | ||||
| 6. Round | 14/08/2021 | TSV Karlburg | - | SpVgg Ansbach | 0:1 | ||||
| 7. Round | 18/08/2021 | DJK Gebenbach | - | TSV Karlburg | 3:0 | ||||
| 8. Round | 21/08/2021 | TSV Karlburg | - | ATSV Erlangen | 1:1 | ||||
| 9. Round | 29/08/2021 | DJK Ammerthal | - | TSV Karlburg | 3:1 | ||||
| 10. Round | 04/09/2021 | TSV Karlburg | - | Vatan Spor Aschaffenburg | 1:1 | ||||
| 11. Round | 11/09/2021 | DJK Vilzing | - | TSV Karlburg | 5:1 | |
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| 12. Round | 19/09/2021 | TSV Karlburg | - | 1. SC Feucht | 0:2 | ||||
| 13. Round | 25/09/2021 | TSV Karlburg | - | ASV Neumarkt | 0:0 | ||||
| 14. Round | 02/10/2021 | Eintracht Bamberg | - | TSV Karlburg | 0:1 | ||||
| 16. Round | 16/10/2021 | 1. FC Sand | - | TSV Karlburg | 1:1 | |
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| 17. Round | 23/10/2021 | TSV Karlburg | - | SpVgg Bayern Hof | 1:1 | ||||
| 18. Round | 30/10/2021 | TSV Karlburg | - | SV Seligenporten | 0:0 | ||||
| 19. Round | 06/11/2021 | TSV Großbardorf | - | TSV Karlburg | 1:0 | ||||
| 21. Round | 20/11/2021 | Würzburger FV | - | TSV Karlburg | 1:1 |
Germany