| 1. Round | 05/09/2020 | 1899 Hoffenheim II | - | 1. FSV Mainz 05 II | 1:2 | ||||
| 2. Round | 12/09/2020 | Bahlinger SC | - | 1899 Hoffenheim II | 1:0 | ||||
| 3. Round | 15/09/2020 | 1899 Hoffenheim II | - | SG Sonnenhof Großaspach | 1:4 | ||||
| 4. Round | 19/09/2020 | Kickers Offenbach | - | 1899 Hoffenheim II | 3:0 | ||||
| 5. Round | 25/09/2020 | FK Pirmasens | - | 1899 Hoffenheim II | 0:2 | ||||
| 7. Round | 03/10/2020 | TSV Steinbach Haiger | - | 1899 Hoffenheim II | 2:0 |  |
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| 8. Round | 10/10/2020 | 1899 Hoffenheim II | - | SC Freiburg II | 0:1 | |
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| 9. Round | 17/10/2020 | Bayern Alzenau | - | 1899 Hoffenheim II | 1:4 | ||||
| 10. Round | 20/10/2020 | 1899 Hoffenheim II | - | SSV Ulm 1846 | 2:1 |  |
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| 11. Round | 24/10/2020 | FC Gießen | - | 1899 Hoffenheim II | 1:2 | ||||
| 12. Round | 30/10/2020 | 1899 Hoffenheim II | - | VfB Stuttgart II | 0:3 | ||||
| 19. Round | 12/12/2020 | FSV Frankfurt | - | 1899 Hoffenheim II | 5:2 | ||||
| 14. Round | 15/12/2020 | 1899 Hoffenheim II | - | Eintracht Stadtallendorf | 2:0 | ||||
| 20. Round | 19/12/2020 | 1899 Hoffenheim II | - | FC-Astoria Walldorf | 3:0 | ||||
| 13. Round | 09/01/2021 | TSV Schott Mainz | - | 1899 Hoffenheim II | 2:2 | |
Germany