| 1. Round | 29/08/2021 | SG Wattenscheid 09 | - | RSV Meinerzhagen | 3:2 | ||||
| 2. Round | 03/09/2021 | RSV Meinerzhagen | - | FCE Rheine | 1:2 |  |
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| 3. Round | 12/09/2021 | TSG Sprockhövel | - | RSV Meinerzhagen | 6:1 |  |
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| 4. Round | 19/09/2021 | RSV Meinerzhagen | - | Hammer SpVg | 2:0 | |
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| 5. Round | 26/09/2021 | Sportfreunde Siegen | - | RSV Meinerzhagen | 3:1 | |
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| 6. Round | 03/10/2021 | RSV Meinerzhagen | - | SpVgg Vreden | 0:1 | ||||
| 7. Round | 10/10/2021 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 | ||||
| 8. Round | 17/10/2021 | RSV Meinerzhagen | - | TuS Haltern | 2:3 | |
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| 9. Round | 24/10/2021 | TuS Erndtebrück | - | RSV Meinerzhagen | 1:0 | ||||
| 13. Round | 20/11/2021 | RSV Meinerzhagen | - | Westfalia Herne | 4:2 | |
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| 14. Round | 28/11/2021 | Westfalia Rhynern | - | RSV Meinerzhagen | 6:0 | ||||
| 15. Round | 05/12/2021 | RSV Meinerzhagen | - | Holzwickeder SC | 4:1 | |
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| 16. Round | 11/12/2021 | ASC 09 Dortmund | - | RSV Meinerzhagen | 4:3 | |
Germany