| 14. Round | 01/12/2010 | FC Schalke 04 II | - | Fortuna Düsseldorf II | 0:0 | ||||
| 20. Round | 12/02/2011 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 1:0 | ||||
| 21. Round | 20/02/2011 | 1. FC Köln II | - | FC Schalke 04 II | 1:1 | ||||
| 18. Round | 01/03/2011 | FC Schalke 04 II | - | FC 08 Homburg | 1:0 | ||||
| 23. Round | 05/03/2011 | 1. FC Kaiserslautern II | - | FC Schalke 04 II | 2:1 | ||||
| 24. Round | 12/03/2011 | FC Schalke 04 II | - | Wuppertaler SV | 3:0 | ||||
| 19. Round | 24/03/2011 | SV 07 Elversberg | - | FC Schalke 04 II | 0:0 | ||||
| 26. Round | 03/04/2011 | FC Schalke 04 II | - | Eintracht Trier | 2:2 | ||||
| 27. Round | 09/04/2011 | Arminia Bielefeld II | - | FC Schalke 04 II | 1:2 | ||||
| 28. Round | 17/04/2011 | FC Schalke 04 II | - | Borussia Dortmund II | 1:5 | ||||
| 29. Round | 24/04/2011 | 1. FSV Mainz 05 II | - | FC Schalke 04 II | 3:0 | ||||
| 30. Round | 30/04/2011 | FC Schalke 04 II | - | Sportfreunde Lotte | 0:1 | ||||
| 31. Round | 07/05/2011 | Fortuna Düsseldorf II | - | FC Schalke 04 II | 1:0 | ||||
| 33. Round | 19/05/2011 | FC Schalke 04 II | - | SC Wiedenbrück | 0:1 | ||||
| 34. Round | 28/05/2011 | Bayer Leverkusen II | - | FC Schalke 04 II | 4:1 |
Germany