| 1. Round | 14/08/2021 | FV Eppelborn | - | TSG Pfeddersheim | 3:6 |  |
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| 3. Round | 25/08/2021 | FV Eppelborn | - | FSV Jägersburg | 1:4 | ||||
| 4. Round | 28/08/2021 | FV 07 Diefflen | - | FV Eppelborn | 2:0 | ||||
| 6. Round | 11/09/2021 | Wormatia Worms | - | FV Eppelborn | 2:0 | ||||
| 7. Round | 18/09/2021 | FV Eppelborn | - | Arminia Ludwigshafen | 0:1 | ||||
| 8. Round | 22/09/2021 | SV 07 Elversberg II | - | FV Eppelborn | 3:2 | ||||
| 9. Round | 25/09/2021 | FV Eppelborn | - | SV Röchling Völklingen | 4:1 | ||||
| 10. Round | 02/10/2021 | FV Eppelborn | - | FC Speyer 09 | 2:1 | ||||
| 14. Round | 27/10/2021 | FSV Jägersburg | - | FV Eppelborn | 0:3 | ||||
| 15. Round | 30/10/2021 | FV Eppelborn | - | FV 07 Diefflen | 3:1 | ||||
| 17. Round | 13/11/2021 | FV Eppelborn | - | Wormatia Worms | 1:1 | ||||
| 19. Round | 24/11/2021 | FV Eppelborn | - | SV 07 Elversberg II | 4:2 | ||||
| 20. Round | 28/11/2021 | SV Röchling Völklingen | - | FV Eppelborn | 2:1 | ||||
| 12. Round | 19/02/2022 | TSG Pfeddersheim | - | FV Eppelborn | 3:0 | ||||
| 16. Round | 09/03/2022 | FC Hertha Wiesbach | - | FV Eppelborn | 6:0 |
Germany