| 1. Round | 06/08/2005 | 1. FC Köln | - | 1. FSV Mainz 05 | 1:0 | ||||
| 2. Round | 14/08/2005 | VfB Stuttgart | - | 1. FC Köln | 2:3 |  |
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| 4. Round | 11/09/2005 | Borussia Dortmund | - | 1. FC Köln | 2:1 | ||||
| 5. Round | 17/09/2005 | 1. FC Köln | - | Bor. Mönchengladbach | 2:1 | ||||
| 6. Round | 21/09/2005 | Bayer Leverkusen | - | 1. FC Köln | 2:1 | ||||
| 7. Round | 25/09/2005 | 1. FC Köln | - | Hertha BSC | 0:1 | ||||
| 9. Round | 16/10/2005 | 1. FC Köln | - | Hannover 96 | 1:4 | ||||
| 10. Round | 22/10/2005 | Eintracht Frankfurt | - | 1. FC Köln | 6:3 | ||||
| 16. Round | 11/12/2005 | 1. FC Köln | - | Werder Bremen | 1:4 |  |
Zambia