| 7. Round | 07/11/2021 | Bayer Leverkusen [Women] | - | 1. FC Köln [Women] | 3:4 | ||||
| 8. Round | 14/11/2021 | 1899 Hoffenheim [Women] | - | Bayer Leverkusen [Women] | 7:1 | ||||
| 9. Round | 21/11/2021 | Bayer Leverkusen [Women] | - | Eintracht Frankfurt [Women] | 0:1 |  |
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| 12. Round | 19/12/2021 | Bayer Leverkusen [Women] | - | FC Carl Zeiss Jena [Women] | 2:0 | ||||
| 16. Round | 13/03/2022 | SC Sand [Women] | - | Bayer Leverkusen [Women] | 2:1 | ||||
| 21. Round | 06/05/2022 | Bayer Leverkusen [Women] | - | Bayern München [Women] | 0:3 | ||||
| 22. Round | 15/05/2022 | VfL Wolfsburg [Women] | - | Bayer Leverkusen [Women] | 7:1 |
Germany