| 3. Round | 26/09/2021 | Bayer Leverkusen [Youth B] | - | Fortuna Düsseldorf [Youth B] | 0:2 | ||||
| 4. Round | 02/10/2021 | Arminia Bielefeld [Youth B] | - | Bayer Leverkusen [Youth B] | 0:0 | ||||
| 6. Round | 30/10/2021 | Bayer Leverkusen [Youth B] | - | SV Lippstadt 08 [Youth B] | 2:0 |  |
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| 7. Round | 06/11/2021 | VfL Bochum [Youth B] | - | Bayer Leverkusen [Youth B] | 2:0 | ||||
| 8. Round | 27/11/2021 | Bayer Leverkusen [Youth B] | - | Preußen Münster [Youth B] | 2:3 | |
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| 10. Round | 12/12/2021 | Bayer Leverkusen [Youth B] | - | Fortuna Köln [Youth B] | 2:0 | |
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| 11. Round | 19/02/2022 | Bayer Leverkusen [Youth B] | - | FC Hennef 05 [Youth B] | 0:1 | ||||
| 12. Round | 27/02/2022 | Bayer Leverkusen [Youth B] | - | FC Schalke 04 [Youth B] | 0:5 | ||||
| 13. Round | 06/03/2022 | SC Paderborn 07 [Youth B] | - | Bayer Leverkusen [Youth B] | 1:1 | |
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| 14. Round | 12/03/2022 | Bayer Leverkusen [Youth B] | - | Rot-Weiss Essen [Youth B] | 1:2 |  |
Germany
Turkey