| 8. Round | 28/11/2021 | Rot-Weiss Essen [Youth] | - | Fortuna Köln [Youth] | 2:1 | ||||
| 9. Round | 05/12/2021 | MSV Duisburg [Youth] | - | Rot-Weiss Essen [Youth] | 3:0 | ||||
| 10. Round | 06/02/2022 | Rot-Weiss Essen [Youth] | - | Arminia Bielefeld [Youth] | 0:0 | ||||
| 11. Round | 13/02/2022 | FC Schalke 04 [Youth] | - | Rot-Weiss Essen [Youth] | 1:2 |  |
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| 12. Round | 20/02/2022 | Rot-Weiss Essen [Youth] | - | 1. FC Köln [Youth] | 1:1 | ||||
| 13. Round | 06/03/2022 | Fortuna Düsseldorf [Youth] | - | Rot-Weiss Essen [Youth] | 1:1 | ||||
| 14. Round | 03/04/2022 | Rot-Weiss Essen [Youth] | - | Alemannia Aachen [Youth] | 4:0 | |
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| 15. Round | 09/04/2022 | Bayer Leverkusen [Youth] | - | Rot-Weiss Essen [Youth] | 1:0 | ||||
| 16. Round | 23/04/2022 | Rot-Weiss Essen [Youth] | - | Wuppertaler SV [Youth] | 2:1 | ||||
| 17. Round | 30/04/2022 | Borussia Dortmund [Youth] | - | Rot-Weiss Essen [Youth] | 1:0 |
Germany
North Macedonia