| 2. Round | 20/08/1980 | 1. FC Kaiserslautern | - | VfB Stuttgart | 1:0 | ||||
| 3. Round | 23/08/1980 | Hamburger SV | - | 1. FC Kaiserslautern | 3:2 | ||||
| 4. Round | 02/09/1980 | 1. FC Kaiserslautern | - | TSV 1860 München | 3:2 | ||||
| 5. Round | 05/09/1980 | VfL Bochum | - | 1. FC Kaiserslautern | 0:0 | ||||
| 6. Round | 12/09/1980 | 1. FC Kaiserslautern | - | MSV Duisburg | 1:1 | ||||
| 8. Round | 27/09/1980 | 1. FC Kaiserslautern | - | Karlsruher SC | 1:0 | ||||
| 13. Round | 08/11/1980 | 1. FC Kaiserslautern | - | Bayern München | 4:2 | ||||
| 15. Round | 29/11/1980 | 1. FC Kaiserslautern | - | Fortuna Düsseldorf | 3:0 | ||||
| 27. Round | 14/04/1981 | 1. FC Kaiserslautern | - | Eintracht Frankfurt | 2:0 | ||||
| 29. Round | 18/04/1981 | 1. FC Kaiserslautern | - | Bayer 05 Uerdingen | 4:2 | ||||
| 30. Round | 09/05/1981 | Bayern München | - | 1. FC Kaiserslautern | 3:0 | ||||
| 31. Round | 15/05/1981 | 1. FC Kaiserslautern | - | Borussia Dortmund | 1:1 | ||||
| 33. Round | 06/06/1981 | 1. FC Kaiserslautern | - | FC Schalke 04 | 2:0 |  |
|||
| 34. Round | 13/06/1981 | Arminia Bielefeld | - | 1. FC Kaiserslautern | 0:1 | |
Germany