| 4. Round | 02/10/2021 | Wuppertaler SV [Youth] | - | Arminia Bielefeld [Youth] | 0:1 | ||||
| 5. Round | 17/10/2021 | FC Schalke 04 [Youth] | - | Wuppertaler SV [Youth] | 8:0 | ||||
| 6. Round | 24/10/2021 | Wuppertaler SV [Youth] | - | 1. FC Köln [Youth] | 0:4 | ||||
| 7. Round | 30/10/2021 | Fortuna Düsseldorf [Youth] | - | Wuppertaler SV [Youth] | 0:2 | ||||
| 8. Round | 28/11/2021 | Wuppertaler SV [Youth] | - | Alemannia Aachen [Youth] | 2:1 | ||||
| 9. Round | 05/12/2021 | Bayer Leverkusen [Youth] | - | Wuppertaler SV [Youth] | 7:0 | ||||
| 11. Round | 13/02/2022 | Wuppertaler SV [Youth] | - | Borussia Dortmund [Youth] | 0:4 |  |
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| 12. Round | 20/02/2022 | Viktoria Köln [Youth] | - | Wuppertaler SV [Youth] | 4:0 | |
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| 13. Round | 05/03/2022 | Wuppertaler SV [Youth] | - | Bor. Mönchengladbach [Youth] | 1:1 | ||||
| 14. Round | 03/04/2022 | VfL Bochum [Youth] | - | Wuppertaler SV [Youth] | 3:0 | ||||
| 15. Round | 09/04/2022 | Wuppertaler SV [Youth] | - | Preußen Münster [Youth] | 0:3 | ||||
| 17. Round | 30/04/2022 | Wuppertaler SV [Youth] | - | Rot-Weiß Oberhausen [Youth] | 4:1 |  |
Germany