| 1. Round | 29/08/2021 | TSG Sprockhövel | - | Preußen Münster II | 2:0 dec. |  |
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| 2. Round | 05/09/2021 | SC Paderborn 07 II | - | TSG Sprockhövel | 4:0 | ||||
| 3. Round | 12/09/2021 | TSG Sprockhövel | - | RSV Meinerzhagen | 6:1 | ||||
| 4. Round | 19/09/2021 | Westfalia Herne | - | TSG Sprockhövel | 1:1 | ||||
| 5. Round | 26/09/2021 | TSG Sprockhövel | - | Westfalia Rhynern | 5:0 | ||||
| 6. Round | 03/10/2021 | Holzwickeder SC | - | TSG Sprockhövel | 0:5 | ||||
| 7. Round | 10/10/2021 | TSG Sprockhövel | - | ASC 09 Dortmund | 3:3 | ||||
| 8. Round | 17/10/2021 | SG Finnentrop/Bamenohl | - | TSG Sprockhövel | 2:1 | ||||
| 9. Round | 24/10/2021 | TSG Sprockhövel | - | 1. FC Kaan-Marienborn | 1:6 | ||||
| 10. Round | 31/10/2021 | Viktoria Clarholz | - | TSG Sprockhövel | 1:0 | ||||
| 11. Round | 05/11/2021 | TSG Sprockhövel | - | TuS Ennepetal | 5:2 | ||||
| 12. Round | 14/11/2021 | SV Schermbeck | - | TSG Sprockhövel | 2:0 | ||||
| 14. Round | 13/02/2022 | FCE Rheine | - | TSG Sprockhövel | 2:1 |
Germany