| 2. Round | 19/08/2021 | Viktoria Arnoldsweiler | - | Fortuna Köln II | 3:0 | ||||
| 3. Round | 22/08/2021 | Fortuna Köln II | - | Siegburger SV 04 | 1:2 | ||||
| 5. Round | 05/09/2021 | Fortuna Köln II | - | SV Breinig | 2:0 | ||||
| 8. Round | 26/09/2021 | VfL Alfter | - | Fortuna Köln II | 2:0 | ||||
| 14. Round | 07/11/2021 | Fortuna Köln II | - | SpVg Frechen 20 | 1:1 | ||||
| 16. Round | 28/11/2021 | Blau-Weiß Friesdorf | - | Fortuna Köln II | 1:3 | ||||
| 20. Round | 06/03/2022 | Siegburger SV 04 | - | Fortuna Köln II | 1:1 | ||||
| 18. Round | 10/03/2022 | SV 1914 Eilendorf | - | Fortuna Köln II | 4:0 |
Germany