| 1. Round | 13/08/2021 | 1. FC Magdeburg [Youth] | - | Hallescher FC [Youth] | 1:2 | ||||
| 2. Round | 21/08/2021 | VfL Wolfsburg [Youth] | - | 1. FC Magdeburg [Youth] | 2:1 | ||||
| 6. Round | 02/10/2021 | 1. FC Magdeburg [Youth] | - | 1. FC Union Berlin [Youth] | 0:3 | ||||
| 7. Round | 16/10/2021 | Hannover 96 [Youth] | - | 1. FC Magdeburg [Youth] | 2:0 | ||||
| 8. Round | 23/10/2021 | 1. FC Magdeburg [Youth] | - | Hansa Rostock [Youth] | 3:1 |  |
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| 9. Round | 30/10/2021 | Energie Cottbus [Youth] | - | 1. FC Magdeburg [Youth] | 3:0 | ||||
| 3. Round | 06/11/2021 | 1. FC Magdeburg [Youth] | - | Werder Bremen [Youth] | 1:3 |  |
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| 10. Round | 12/03/2022 | 1. FC Magdeburg [Youth] | - | Hamburger SV [Youth] | 6:2 |
Germany