| 1. Round | 14/08/2021 | 1899 Hoffenheim [Youth B] | - | SV Darmstadt 98 [Youth B] | 4:1 | ||||
| 2. Round | 20/08/2021 | 1. FC Kaiserslautern [Youth B] | - | 1899 Hoffenheim [Youth B] | 5:0 | ||||
| 6. Round | 25/09/2021 | 1899 Hoffenheim [Youth B] | - | Karlsruher SC [Youth B] | 3:0 | ||||
| 7. Round | 03/10/2021 | SV Wehen Wiesbaden [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:6 | ||||
| 16. Round | 26/02/2022 | 1899 Hoffenheim [Youth B] | - | FC Augsburg [Youth B] | 2:2 | ||||
| 17. Round | 06/03/2022 | SpVgg Greuther Fürth [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:2 | ||||
| 18. Round | 12/03/2022 | 1899 Hoffenheim [Youth B] | - | FC Ingolstadt 04 [Youth B] | 1:1 | ||||
| 20. Round | 09/04/2022 | 1899 Hoffenheim [Youth B] | - | SC Freiburg [Youth B] | 1:1 | ||||
| 19. Round | 20/04/2022 | SSV Reutlingen [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:3 | ||||
| 21. Round | 24/04/2022 | Eintracht Frankfurt [Youth B] | - | 1899 Hoffenheim [Youth B] | 3:3 |
Austria