| 2. Round | 21/08/2021 | Holstein Kiel [Youth] | - | FC Carl Zeiss Jena [Youth] | 2:1 |  |
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| 3. Round | 11/09/2021 | FC Carl Zeiss Jena [Youth] | - | RB Leipzig [Youth] | 0:1 | ||||
| 4. Round | 18/09/2021 | Chemnitzer FC [Youth] | - | FC Carl Zeiss Jena [Youth] | 1:1 | ||||
| 5. Round | 25/09/2021 | FC Carl Zeiss Jena [Youth] | - | Eimsbütteler TV [Youth] | 4:1 |  |
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| 6. Round | 02/10/2021 | Dynamo Dresden [Youth] | - | FC Carl Zeiss Jena [Youth] | 4:0 | ||||
| 7. Round | 17/10/2021 | FC Carl Zeiss Jena [Youth] | - | FC Viktoria 1889 Berlin [Youth] | 0:1 | ||||
| 8. Round | 23/10/2021 | Hallescher FC [Youth] | - | FC Carl Zeiss Jena [Youth] | 3:1 | ||||
| 10. Round | 09/02/2022 | Werder Bremen [Youth] | - | FC Carl Zeiss Jena [Youth] | 3:2 | ||||
| 15. Round | 05/03/2022 | FC Carl Zeiss Jena [Youth] | - | Hansa Rostock [Youth] | 0:3 | ||||
| 16. Round | 02/04/2022 | Energie Cottbus [Youth] | - | FC Carl Zeiss Jena [Youth] | 3:0 |  |
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| 18. Round | 23/04/2022 | FC St. Pauli [Youth] | - | FC Carl Zeiss Jena [Youth] | 2:0 | |
Germany