| 1. Round | 15/08/2021 | 1. FSV Mainz 05 [Youth] | - | Karlsruher SC [Youth] | 1:3 | ||||
| 3. Round | 10/09/2021 | Karlsruher SC [Youth] | - | FC-Astoria Walldorf [Youth] | 0:0 | ||||
| 4. Round | 18/09/2021 | FC Ingolstadt 04 [Youth] | - | Karlsruher SC [Youth] | 2:2 | ||||
| 6. Round | 02/10/2021 | 1. FC Kaiserslautern [Youth] | - | Karlsruher SC [Youth] | 4:3 |  |
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| 5. Round | 13/11/2021 | Karlsruher SC [Youth] | - | SpVgg Unterhaching [Youth] | 0:0 | ||||
| 10. Round | 20/11/2021 | Kickers Offenbach [Youth] | - | Karlsruher SC [Youth] | 5:1 | ||||
| 11. Round | 26/11/2021 | Karlsruher SC [Youth] | - | SC Freiburg [Youth] | 1:1 | ||||
| 12. Round | 05/12/2021 | SSV Ulm 1846 [Youth] | - | Karlsruher SC [Youth] | 0:5 |
Germany