| 1. Round | 30/08/1980 | BSG MK Sangerhausen | - | BSG Chemie Buna Schkopau | 1:3 | ||||
| 2. Round | 06/09/1980 | BSG Chemie Buna Schkopau | - | Chemie Schönebeck | 2:1 | ||||
| 12. Round | 29/11/1980 | BSG Chemie Buna Schkopau | - | BSG MK Sangerhausen | 5:2 | ||||
| 14. Round | 12/12/1980 | BSG Chemie Buna Schkopau | - | BSG Stahl Nordwest Leipzig | 4:2 | ||||
| 15. Round | 28/02/1981 | ASG Vorwärts Dessau | - | BSG Chemie Buna Schkopau | 0:1 | ||||
| 16. Round | 07/03/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Leipzig | 3:2 | ||||
| 17. Round | 14/03/1981 | BSG Stahl Thale | - | BSG Chemie Buna Schkopau | 1:1 | ||||
| 18. Round | 21/03/1981 | BSG Chemie Buna Schkopau | - | SG Dynamo Eisleben | 1:1 | ||||
| 19. Round | 28/03/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Wolfen | 0:0 | ||||
| 20. Round | 03/04/1981 | BSG Lokomotive Stendal | - | BSG Chemie Buna Schkopau | 1:1 | ||||
| 21. Round | 11/04/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Zeitz | 3:0 | ||||
| 22. Round | 16/04/1981 | BSG Stahl Blankenburg | - | BSG Chemie Buna Schkopau | 2:2 |  |
Germany