| 3. Round | 06/09/1980 | FC Karl-Marx-Stadt | - | BSG Wismut Aue | 0:0 | ||||
| 4. Round | 13/09/1980 | BSG Wismut Aue | - | Hansa Rostock | 1:0 |  |
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| 5. Round | 20/09/1980 | BSG Chemie Böhlen | - | BSG Wismut Aue | 1:0 | ||||
| 6. Round | 27/09/1980 | BSG Wismut Aue | - | BFC Dynamo | 0:5 | ||||
| 10. Round | 08/11/1980 | BSG Wismut Aue | - | BSG Sachsenring Zwickau | 2:1 | ||||
| 11. Round | 15/11/1980 | 1. FC Lokomotive Leipzig | - | BSG Wismut Aue | 6:1 | ||||
| 12. Round | 22/11/1980 | BSG Wismut Aue | - | FC Vorwärts Frankfurt/Oder | 1:1 |  |
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| 13. Round | 29/11/1980 | 1. FC Magdeburg | - | BSG Wismut Aue | 4:1 | ||||
| 14. Round | 21/02/1981 | BSG Wismut Aue | - | Dynamo Dresden | 3:1 | ||||
| 17. Round | 14/03/1981 | Hansa Rostock | - | BSG Wismut Aue | 4:1 | ||||
| 21. Round | 15/04/1981 | FC Carl Zeiss Jena | - | BSG Wismut Aue | 2:0 |
Germany