| 3. Round | 25/08/2018 | SC Paderborn 07 II | - | FC Schalke 04 II | 1:4 | ||||
| 9. Round | 07/10/2018 | FC Schalke 04 II | - | TSG Sprockhövel | 3:0 | ||||
| 12. Round | 26/10/2018 | Sportfreunde Siegen | - | FC Schalke 04 II | 0:1 | ||||
| 16. Round | 02/12/2018 | Westfalia Rhynern | - | FC Schalke 04 II | 0:3 | ||||
| 18. Round | 15/12/2018 | FC Schalke 04 II | - | Westfalia Herne | 3:1 | ||||
| 19. Round | 10/02/2019 | FCE Rheine | - | FC Schalke 04 II | 0:4 | ||||
| 23. Round | 17/03/2019 | FC Schalke 04 II | - | TuS Ennepetal | 3:0 | ||||
| 24. Round | 24/03/2019 | Hammer SpVg | - | FC Schalke 04 II | 1:3 | ||||
| 25. Round | 31/03/2019 | FC Schalke 04 II | - | FC Brünninghausen | 2:0 | ||||
| 29. Round | 22/04/2019 | FC Schalke 04 II | - | Sportfreunde Siegen | 7:0 | ||||
| 31. Round | 04/05/2019 | FC Schalke 04 II | - | FC Gütersloh | 2:0 | ||||
| 32. Round | 12/05/2019 | Rot Weiss Ahlen | - | FC Schalke 04 II | 1:2 | ||||
| 33. Round | 19/05/2019 | FC Schalke 04 II | - | Westfalia Rhynern | 3:0 |
Germany