| 5. Round | 18/09/2021 | SC Velbert | - | FSV Duisburg | 2:0 | ||||
| 6. Round | 26/09/2021 | VfB 03 Hilden | - | SC Velbert | 3:3 | ||||
| 8. Round | 10/10/2021 | SC Velbert | - | Sportfreunde Niederwenigern | 1:2 | ||||
| 9. Round | 17/10/2021 | TV Jahn Hiesfeld | - | SC Velbert | 2:1 | ||||
| 10. Round | 24/10/2021 | SC Velbert | - | SpVg Schonnebeck | 1:3 | ||||
| 11. Round | 31/10/2021 | Cronenberger SC | - | SC Velbert | 1:1 | ||||
| 12. Round | 07/11/2021 | SC Velbert | - | SC Union Nettetal | 1:1 | ||||
| 13. Round | 14/11/2021 | SC Düsseldorf-West | - | SC Velbert | 2:0 | ||||
| 14. Round | 27/11/2021 | SC Velbert | - | Sportfreunde Baumberg | 0:3 | ||||
| 15. Round | 03/12/2021 | 1. FC Kleve | - | SC Velbert | 8:0 | ||||
| 16. Round | 11/12/2021 | SC Velbert | - | TSV Meerbusch | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Bocholt | - | SC Velbert | 5:0 |
Germany