| 1. Round | 14/08/2022 | SpVgg Unterhaching [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:4 |  |
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| 3. Round | 27/08/2022 | 1899 Hoffenheim [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 6:2 | |
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| 4. Round | 02/09/2022 | FC-Astoria Walldorf [Youth B] | - | 1899 Hoffenheim [Youth B] | 0:2 | ||||
| 6. Round | 17/09/2022 | FC Augsburg [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:2 | ||||
| 7. Round | 01/10/2022 | 1899 Hoffenheim [Youth B] | - | Karlsruher SC [Youth B] | 3:1 | ||||
| 8. Round | 09/10/2022 | 1. FC Nürnberg [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:3 |  |
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| 10. Round | 05/11/2022 | Jahn Regensburg [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:5 | ||||
| 15. Round | 25/02/2023 | 1899 Hoffenheim [Youth B] | - | Bayern München [Youth B] | 3:1 | ||||
| 16. Round | 04/03/2023 | Stuttgarter Kickers [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:3 | ||||
| 17. Round | 11/03/2023 | 1899 Hoffenheim [Youth B] | - | SC Freiburg [Youth B] | 4:0 | |
Angola