| 1. Round | 07/08/2010 | FC 08 Homburg | - | FC Schalke 04 II | 1:2 | ||||
| 2. Round | 21/08/2010 | FC Schalke 04 II | - | SV 07 Elversberg | 0:0 | ||||
| 3. Round | 27/08/2010 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 0:1 | ||||
| 4. Round | 08/09/2010 | FC Schalke 04 II | - | 1. FC Köln II | 1:0 | ||||
| 5. Round | 11/09/2010 | SC Verl | - | FC Schalke 04 II | 4:1 | ||||
| 6. Round | 18/09/2010 | FC Schalke 04 II | - | 1. FC Kaiserslautern II | 1:0 | ||||
| 7. Round | 21/09/2010 | Wuppertaler SV | - | FC Schalke 04 II | 2:4 | ||||
| 15. Round | 20/11/2010 | FC Schalke 04 II | - | VfL Bochum II | 2:1 | ||||
| 14. Round | 01/12/2010 | FC Schalke 04 II | - | Fortuna Düsseldorf II | 0:0 | ||||
| 17. Round | 05/12/2010 | FC Schalke 04 II | - | Bayer Leverkusen II | 1:1 | ||||
| 16. Round | 29/01/2011 | SC Wiedenbrück | - | FC Schalke 04 II | 1:0 | ||||
| 20. Round | 12/02/2011 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 1:0 | ||||
| 21. Round | 20/02/2011 | 1. FC Köln II | - | FC Schalke 04 II | 1:1 |  |
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