| 3. Round | 28/08/2021 | FT Braunschweig | - | U.S.I. Lupo-Martini | 1:1 |  |
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| 4. Round | 05/09/2021 | U.S.I. Lupo-Martini | - | Eintracht Northeim | 4:1 | ||||
| 5. Round | 12/09/2021 | U.S.I. Lupo-Martini | - | HSC/BW Tündern | 4:0 | ||||
| 6. Round | 19/09/2021 | SVG Göttingen 07 | - | U.S.I. Lupo-Martini | 0:0 | ||||
| 8. Round | 02/10/2021 | MTV Wolfenbüttel | - | U.S.I. Lupo-Martini | 0:4 | ||||
| 9. Round | 10/10/2021 | U.S.I. Lupo-Martini | - | MTV Gifhorn | 3:0 | ||||
| 12. Round | 31/10/2021 | U.S.I. Lupo-Martini | - | FT Braunschweig | 3:0 | ||||
| 13. Round | 07/11/2021 | Eintracht Northeim | - | U.S.I. Lupo-Martini | 1:3 | ||||
| 14. Round | 13/11/2021 | HSC/BW Tündern | - | U.S.I. Lupo-Martini | 5:2 | ||||
| 15. Round | 21/11/2021 | U.S.I. Lupo-Martini | - | SVG Göttingen 07 | 3:0 | ||||
| 16. Round | 28/11/2021 | Arminia Hannover | - | U.S.I. Lupo-Martini | 0:0 | ||||
| 17. Round | 04/12/2021 | U.S.I. Lupo-Martini | - | MTV Wolfenbüttel | 2:3 |
Germany