| 14. Round | 27/02/2022 | Borussia Bocholt [Women] | - | SG 99 Andernach [Women] | 0:4 | ||||
| 15. Round | 16/03/2022 | SG 99 Andernach [Women] | - | SV 07 Elversberg [Women] | 4:2 |  |
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| 17. Round | 20/03/2022 | SG 99 Andernach [Women] | - | 1. FC Nürnberg [Women] | 0:1 | ||||
| 16. Round | 23/03/2022 | FC Ingolstadt 04 [Women] | - | SG 99 Andernach [Women] | 0:1 | ||||
| 18. Round | 27/03/2022 | SV Henstedt-Ulzburg [Women] | - | SG 99 Andernach [Women] | 1:3 | ||||
| 20. Round | 17/04/2022 | MSV Duisburg [Women] | - | SG 99 Andernach [Women] | 3:0 | |
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| 19. Round | 20/04/2022 | SG 99 Andernach [Women] | - | RB Leipzig [Women] | 5:0 | ||||
| 21. Round | 24/04/2022 | SG 99 Andernach [Women] | - | VfL Wolfsburg II [Women] | 3:0 | ||||
| 22. Round | 01/05/2022 | 1899 Hoffenheim II [Women] | - | SG 99 Andernach [Women] | 0:3 | ||||
| 23. Round | 08/05/2022 | SG 99 Andernach [Women] | - | Bayern München II [Women] | 2:1 | ||||
| 25. Round | 22/05/2022 | SG 99 Andernach [Women] | - | SV Meppen [Women] | 1:3 |
Germany