| 1. Round | 12/09/2021 | Rot-Weiss Essen [Youth] | - | Viktoria Köln [Youth] | 4:1 | ||||
| 2. Round | 19/09/2021 | Bor. Mönchengladbach [Youth] | - | Rot-Weiss Essen [Youth] | 0:1 | ||||
| 3. Round | 26/09/2021 | Rot-Weiss Essen [Youth] | - | VfL Bochum [Youth] | 2:2 | ||||
| 4. Round | 02/10/2021 | Preußen Münster [Youth] | - | Rot-Weiss Essen [Youth] | 3:1 |  |
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| 6. Round | 24/10/2021 | Rot-Weiss Essen [Youth] | - | Rot-Weiß Oberhausen [Youth] | 1:0 | |
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| 7. Round | 31/10/2021 | SC Paderborn 07 [Youth] | - | Rot-Weiss Essen [Youth] | 3:4 | ||||
| 8. Round | 28/11/2021 | Rot-Weiss Essen [Youth] | - | Fortuna Köln [Youth] | 2:1 | ||||
| 9. Round | 05/12/2021 | MSV Duisburg [Youth] | - | Rot-Weiss Essen [Youth] | 3:0 | ||||
| 11. Round | 13/02/2022 | FC Schalke 04 [Youth] | - | Rot-Weiss Essen [Youth] | 1:2 | ||||
| 12. Round | 20/02/2022 | Rot-Weiss Essen [Youth] | - | 1. FC Köln [Youth] | 1:1 | ||||
| 14. Round | 03/04/2022 | Rot-Weiss Essen [Youth] | - | Alemannia Aachen [Youth] | 4:0 |
Germany