| 1. Round | 22/08/2021 | TV Jahn Hiesfeld | - | FC Kray | 1:4 | ||||
| 2. Round | 29/08/2021 | DJK Teutonia St. Tönis | - | TV Jahn Hiesfeld | 4:1 | ||||
| 3. Round | 05/09/2021 | TV Jahn Hiesfeld | - | TuRU Düsseldorf | 1:2 | ||||
| 4. Round | 10/09/2021 | Germania Ratingen 04/19 | - | TV Jahn Hiesfeld | 0:0 | ||||
| 5. Round | 19/09/2021 | TV Jahn Hiesfeld | - | 1. FC Monheim | 0:2 | ||||
| 6. Round | 26/09/2021 | 1. FC Mönchengladbach | - | TV Jahn Hiesfeld | 0:8 | ||||
| 13. Round | 14/11/2021 | Cronenberger SC | - | TV Jahn Hiesfeld | 2:0 | ||||
| 14. Round | 28/11/2021 | TV Jahn Hiesfeld | - | SC Union Nettetal | 1:3 | ||||
| 15. Round | 03/12/2021 | SC Düsseldorf-West | - | TV Jahn Hiesfeld | 1:2 | ||||
| 16. Round | 12/12/2021 | TV Jahn Hiesfeld | - | Sportfreunde Baumberg | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Kleve | - | TV Jahn Hiesfeld | 5:1 |  |
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| 19. Round | 27/02/2022 | 1. FC Bocholt | - | TV Jahn Hiesfeld | 3:0 | ||||
| 20. Round | 06/03/2022 | TV Jahn Hiesfeld | - | SSVg Velbert | 1:0 | ||||
| 21. Round | 13/03/2022 | TVD Velbert | - | TV Jahn Hiesfeld | 4:0 | ||||
| 22. Round | 18/03/2022 | TV Jahn Hiesfeld | - | SpVgg Sterkrade-Nord | 4:3 | ||||
| 23. Round | 27/03/2022 | Schwarz-Weiß Essen | - | TV Jahn Hiesfeld | 4:2 |
Germany