| 1. Round | 22/08/2010 | SpVgg Greuther Fürth | - | Karlsruher SC | 4:1 |  |
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| 11. Round | 08/11/2010 | VfL Osnabrück | - | Karlsruher SC | 0:0 | ||||
| 12. Round | 12/11/2010 | Karlsruher SC | - | Erzgebirge Aue | 1:1 | ||||
| 16. Round | 10/12/2010 | Karlsruher SC | - | Arminia Bielefeld | 1:0 | ||||
| 17. Round | 20/12/2010 | 1. FC Union Berlin | - | Karlsruher SC | 3:1 |
Germany